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3rd Annual SPECT/CT symposium: current status and future directions of SPECT/CT 24 Feb 2014

The most influential recent development in radionuclide imaging was by far the introduction of multi-modality systems combining functional PET or SPECT imaging with CT. While initially the incentive for this was acceleration of transmission scanning for attenuation correction in PET, leading to improved patient throughput and cost effectiveness, soon the diagnostic enhancement of functional imaging by the addition of anatomical localisation was acknowledged and rapidly established in clinical practice. It was not until later around the mid-2000s when the impact of hybrid SPECT/CT became clearer with the introduction of multi-detector CT components allowing structural imaging at improved versatility and image quality.
This was a paradigm shift for SPECT/CT which until then operated CT components attached to a single gantry with the gamma camera thus of fixed limited CT image quality especially in terms of axial slice thickness. The rapid growth of high-end SPECT/CT has brought up capabilities of varying CT acquisition parameters reflecting the diverse needs of different clinical applications in terms of image quality such as voxel resolution and signal-to-noise levels. An assessment of this relationship between adequate image quality and radiation dose is critical in the context of defined disease pathways.

This video is an introduction to SPECT/CT and the current state of instrumentation and methodology will be presented with the aim to set the scene of technical background that may underpin clinical applications discussed at the meeting.

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Duration:25 mins


Speaker info

Dr Lefteris Livieratos

Dr Livieratos is a Medical Physicist in Nuclear Medicine at Guy’s & St Thomas’ Hospitals and Senior Clinical Lecturer in Imaging Sciences at King’s College, London. He has worked in PET methodology at Hammersmith Hospital alongside the MRC PET Oncology and PET Cardiology research groups on radiotracer image-based quantification and novel schemes for patient motion correction such as respiratory motion correction of PET projection data. He subsequently worked as a Clinical Scientist at Guy’s & St Thomas’ involved with diagnostic and therapeutic applications, including the clinical implementation of the first SPECT/CT in Europe with diagnostic 16-slice CT. He is now involved with teaching of radionuclide imaging physics at King’s College and the supervision of students and trainee clinical scientists. His research interests include multi-modality imaging, image quantification and tracer kinetics methodology for translational applications and patient-specific dosimetry in targeted radionuclide therapy.